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Experiment

Lipid Profile on Sarm1-/- animals (MEFUMICH0318b)
Summary Data Summary
Investigator Feldman, Eva
Description Sarm1-/- animals are protected from axonal degeneration and in this project we
wanted to see if silencing Sarm1 would protect from diabetic injury in the
peripheral nervous system.

Our preliminary results show that diabetic Sarm1-/- animals do not develop
sensory or motor nerve conduction deficits.

Applicable research area(s): Diabetes, Metabolism, Neurobiology
Status Completed
Public Release 9/20/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals28
Experimental Conditions4
Catalog Items4
Curation Info (# flags)1
Phenotype Assays10
Phenotype Measurements280
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
5
0
BKS db
0
11
0
B6.129X1- Sarm1tm1Aidi
0
12
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Food Intake

 Ad libitium
Animals are allowed to eat without restrictions.
 Calorie Restriction
The food provided to the animals was restricted based on the number of calories allowed.

Experimental Factor: Mouse Diet

 Research Diets - D12450B
Research Diets - D12450B Rodent Diet with 10% kcal% fat.
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat



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