mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Diet-dependent sex differences in the response to vertical sleeve gastrectomy.
Authors Hutch CR, Stelmak D, Kanke M, Koch-Laskowski K, Cummings B, Griffin C, Leix K,
Sethupathy P, Singer K, Sandoval DA
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal American journal of physiology. Endocrinology and metabolism
Year 2021
Date Published 7/1/2021
Volume : Pages 321 : E11 - E23
PubMed Reference 33998293
Abstract Nearly 80% of patients that receive bariatric surgery are women, yet mechanistic
preclinical studies have focused on males. The goal of this study was to
determine the metabolic impact of diet- and surgery-induced weight loss in
males, females, and ovariectomized females. All mice were fed a 60% high-fat
diet (HFD) before undergoing either vertical sleeve gastrectomy (VSG) or sham
surgery. Mice either remained on an HFD or were switched to a standard chow diet
postsurgically. When maintained on an HFD, males and females decreased fat mass
and improved oral glucose tolerance after VSG. After dietary intervention,
additional adiposity was lost in both surgical groups. Ovariectomized females
showed a blunted decrease in fat mass on an HFD, but lost significant adiposity
after dietary intervention. Energy expenditure was impacted by dietary and not
surgical intervention across all groups. Males decreased hepatic triglyceride
levels after VSG, which was further decreased after dietary intervention. Intact
and ovariectomized females had a blunted decrease in hepatic triglycerides after
VSG, but a significant decrease after dietary intervention. The more pronounced
effect of VSG on hepatic lipids in males is strongly associated with changes in
hepatic expression of genes and microRNAs previously linked to hepatic lipid
regulation and systemic energy homeostasis. These data highlight the importance
of postsurgical diet on metabolic outcomes across sexes. Furthermore, these data
suggest the impact of VSG on hepatic triglycerides is diet-dependent in females
and support the hypothesis that males and females achieve similar metabolic
outcome, at least within the liver, via distinct mechanisms.NEW & NOTEWORTHY
These data highlight the interaction of postsurgical diet after bariatric
surgery on metabolic outcomes across sexes. These data suggest the impact of VSG
on hepatic triglycerides is diet-dependent in females and support the hypothesis
that males and females achieve similar metabolic outcome, at least within the
liver, via distinct mechanisms.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.