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Publication
Molecular topography of an entire nervous system.
Authors Taylor SR, Santpere G, Weinreb A, Barrett A, Reilly MB, Xu C, Varol E, Oikonomou
P, Glenwinkel L, McWhirter R, Poff A, Basavaraju M, Rafi I, Yemini E, Cook SJ,
Abrams A, Vidal B, Cros C, Tavazoie S, Sestan N, Hammarlund M, Hobert O, Miller
DM
Submitted By Submitted Externally on 1/10/2022
Status Published
Journal Cell
Year 2021
Date Published 8/1/2021
Volume : Pages 184 : 4329 - 4347.e23
PubMed Reference 34237253
Abstract We have produced gene expression profiles of all 302 neurons of the C. elegans
nervous system that match the single-cell resolution of its anatomy and wiring
diagram. Our results suggest that individual neuron classes can be solely
identified by combinatorial expression of specific gene families. For example,
each neuron class expresses distinct codes of ~23 neuropeptide genes and ~36
neuropeptide receptors, delineating a complex and expansive "wireless" signaling
network. To demonstrate the utility of this comprehensive gene expression
catalog, we used computational approaches to (1) identify cis-regulatory
elements for neuron-specific gene expression and (2) reveal adhesion proteins
with potential roles in process placement and synaptic specificity. Our
expression data are available at https://cengen.org and can be interrogated at
the web application CengenApp. We expect that this neuron-specific directory of
gene expression will spur investigations of underlying mechanisms that define
anatomy, connectivity, and function throughout the C. elegans nervous system.




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