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Publication
17a-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons
to reduce feeding behavior.
Authors Steyn FJ, Ngo ST, Chen VP, Bailey-Downs LC, Xie TY, Ghadami M, Brimijoin S,
Freeman WM, Rubinstein M, Low MJ, Stout MB
Submitted By Submitted Externally on 1/10/2022
Status Published
Journal Aging cell
Year 2018
Date Published 2/1/2018
Volume : Pages 17 : Not Specified
PubMed Reference 29168299
Abstract Weight loss is an effective intervention for diminishing disease burden in obese
older adults. Pharmacological interventions that reduce food intake and thereby
promote weight loss may offer effective strategies to reduce age-related
disease. We previously reported that 17a-estradiol (17a-E2) administration
elicits beneficial effects on metabolism and inflammation in old male mice.
These observations were associated with reduced calorie intake. Here, we
demonstrate that 17a-E2 acts through pro-opiomelanocortin (Pomc) expression in
the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of
obesity. These results confirm that 17a-E2 modulates appetite through selective
interactions within hypothalamic anorexigenic pathways. Interestingly, some
peripheral markers of metabolic homeostasis were also improved in animals with
near complete loss of ARC Pomc transcription. This suggests that 17a-E2 might
have central and peripheral actions that can beneficially affect metabolism
cooperatively or independently.




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