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Publication
Polymeric stent materials dysregulate macrophage and endothelial cell functions:
implications for coronary artery stent.
Authors Wang X, Zachman AL, Chun YW, Shen FW, Hwang YS, Sung HJ
Submitted By Submitted Externally on 8/5/2014
Status Published
Journal International journal of cardiology
Year 2014
Date Published 7/1/2014
Volume : Pages 174 : 688 - 695
PubMed Reference 24820736
Abstract Biodegradable polymers have been applied as bulk or coating materials for
coronary artery stents. The degradation of polymers, however, could induce
endothelial dysfunction and aggravate neointimal formation. Here we use
polymeric microparticles to simulate and demonstrate the effects of degraded
stent materials on phagocytic activity, cell death and dysfunction of
macrophages and endothelial cells.




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