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Publication
Bone marrow from blotchy mice is dispensable to regulate blood copper and aortic
pathologies but required for inflammatory mediator production in LDLR-deficient
mice during chronic angiotensin II infusion.
Authors Harris D, Liang Y, Chen C, Li S, Patel O, Qin Z
Submitted By Zhenyu Qin on 7/24/2015
Status Published
Journal Annals of vascular surgery
Year 2015
Date Published 2/1/2015
Volume : Pages 29 : 328 - 340
PubMed Reference 25449986
Abstract The blotchy mouse caused by mutations of ATP7A develops low blood copper and
aortic aneurysm and rupture. Although the aortic pathologies are believed
primarily due to congenital copper deficiencies in connective tissue, perinatal
copper supplementation does not produce significant therapeutic effects, hinting
additional mechanisms in the symptom development, such as an independent effect
of the ATP7A mutations during adulthood.




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