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Publication
Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout
mice.
Authors Krüger J, Brachs S, Trappiel M, Kintscher U, Meyborg H, Wellnhofer E,
Thöne-Reineke C, Stawowy P, Östman A, Birkenfeld AL, Böhmer FD, Kappert K
Submitted By Submitted Externally on 7/24/2015
Status Published
Journal Molecular metabolism
Year 2015
Date Published 4/1/2015
Volume : Pages 4 : 325 - 336
PubMed Reference 25830095
Abstract Insulin resistance can be triggered by enhanced dephosphorylation of the insulin
receptor or downstream components in the insulin signaling cascade through
protein tyrosine phosphatases (PTPs). Downregulating density-enhanced
phosphatase-1 (DEP-1) resulted in an improved metabolic status in previous
analyses. This phenotype was primarily caused by hepatic DEP-1 reduction.




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