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Publication
Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin
Resistance.
Authors Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL,
Russo L, Patel PR, Kaw MK, Raphael CK, Kim AJ, Heinrich G, Lee AD, Kim JK,
Kulkarni RN, Philbrick WM, Najjar SM
Submitted By Submitted Externally on 10/1/2015
Status Published
Journal Diabetes
Year 2015
Date Published 8/1/2015
Volume : Pages 64 : 2780 - 90
PubMed Reference 25972571
Abstract Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates
insulin sensitivity by promoting hepatic insulin clearance. Liver-specific
inactivation or global null-mutation of Ceacam1 impairs hepatic insulin
extraction to cause chronic hyperinsulinemia, resulting in insulin resistance
and visceral obesity. In this study we investigated whether diet-induced insulin
resistance implicates changes in hepatic CEACAM1. We report that feeding
C57/BL6J mice a high-fat diet reduced hepatic CEACAM1 levels by >50% beginning
at 21 days, causing hyperinsulinemia, insulin resistance, and elevation in
hepatic triacylglycerol content. Conversely, liver-specific inducible CEACAM1
expression prevented hyperinsulinemia and markedly limited insulin resistance
and hepatic lipid accumulation that were induced by prolonged high-fat intake.
This was partly mediated by increased hepatic ß-fatty acid oxidation and energy
expenditure. The data demonstrate that the high-fat diet reduced hepatic CEACAM1
expression and that overexpressing CEACAM1 in liver curtailed diet-induced
metabolic abnormalities by protecting hepatic insulin clearance.








Genes
SymbolDescription
Apoa1apolipoprotein A-I
Ceacam1CEA-related cell adhesion molecule 1

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