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Publication
Effects of fish oil supplementation on prefrontal metabolite concentrations in
adolescents with major depressive disorder: A preliminary (1)H MRS study.
Authors McNamara RK, Jandacek R, Rider T, Tso P, Chu WJ, Weber WA, Welge JA, Strawn JR,
Adler CM, DelBello MP
Submitted By Submitted Externally on 10/1/2015
Status Published
Journal Nutritional neuroscience
Year 2014
Date Published 6/1/2014
Volume : Pages Not Specified : Not Specified
PubMed Reference 24915543
Abstract Objective To use proton magnetic resonance spectroscopy ((1)H MRS) to
investigate the effects of fish oil (FO) supplementation on cortical metabolite
concentrations in adolescents with major depressive disorder (MDD). Methods
Metabolite concentrations were determined by (1)H MRS in the anterior cingulate
cortex and bilateral dorsolateral prefrontal cortex (DLPFC) of adolescents with
MDD before and following 10-week open-label supplementation with low (2.4 g/day,
n = 7) or high (16.2 g/day, n = 7) dose FO. Depressive symptom severity scores
and erythrocyte fatty acid levels were also determined. Results Baseline
erythrocyte eicosapentaenoic acid (EPA) composition was positively correlated,
and arachidonic acid (AA) and the AA/EPA ratio were inversely correlated, with
choline (Cho) concentrations in the right DLPFC. Docosahexaenoic acid (DHA)
composition was inversely correlated with myo-inositol (mI) concentrations in
the left DLPFC. Erythrocyte EPA and DHA composition increased, and AA decreased,
significantly following low-dose and high-dose FO supplementation. In the
intent-to-treat sample, depressive symptom severity scores decreased
significantly in the high-dose group (-40%, P < 0.0001) and there was a trend in
the low-dose group (-20%, P = 0.06). There were no significant baseline-endpoint
changes in metabolite levels in each voxel. In the low-dose group there were
changes with large effect sizes, including a decrease in mI in the left DLPFC
(-12%, P = 0.18, d = 0.8) and increases in glutamate + glutamine (Glx) (+12%,
P = 0.19, d = 0.8) and Cho (+15%, P = 0.08, d = 1.2) in the right DLPFC. In the
high-dose group, there was a trend for increases in Cho in the right DLPFC
(+10%, P = 0.09, d = 1.2). Discussion These preliminary data suggest that
increasing the LCn-3 fatty acid status of adolescent MDD patients is associated
with subtle changes in Glx, mI, and Cho concentrations in the DLPFC that warrant
further evaluation in a larger controlled trial.




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