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Publication
Decreased adiposity and enhanced glucose tolerance in shikonin treated mice.
Authors Bettaieb A, Hosein E, Chahed S, Abdulaziz A, Kucera HR, Gaikwad NW, Haj FG
Submitted By Submitted Externally on 11/3/2015
Status Published
Journal Obesity (Silver Spring, Md.)
Year 2015
Date Published 9/1/2015
Volume : Pages Not Specified : Not Specified
PubMed Reference 26374090
Abstract Obesity represents a major public health problem, and identifying natural
compounds that modulate energy balance and glucose homeostasis is of interest
for combating obesity and its associated disorders. The naphthoquinone shikonin
has diverse beneficial properties including anti-inflammatory, anti-oxidant, and
anti-microbial effects. The objective of this study is to investigate the
effects of shikonin on adiposity and glucose homeostasis., The metabolic effects
of shikonin treatment on mice fed regular chow or challenged with a high-fat
diet (HFD) were determined., Shikonin treated mice fed regular chow exhibited
improved glucose tolerance compared with controls. In addition, shikonin treated
mice fed HFD displayed decreased weight gain and resistance to HFD-induced
glucose intolerance. Further, shikonin treatment decreased HFD-induced hepatic
dyslipidemia. These findings correlated with enhanced hepatic insulin signaling
in shikonin treated mice as evidenced by increased tyrosyl phosphorylation of
the insulin receptor and enhanced downstream signaling., These studies identify
shikonin as a potential regulator of systemic glucose tolerance, energy balance,
and adiposity in vivo.




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