mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Sensory and spinal inhibitory dorsal midline crossing is independent of Robo3.
Authors Comer JD, Pan FC, Willet SG, Haldipur P, Millen KJ, Wright CV, Kaltschmidt JA
Submitted By Submitted Externally on 11/3/2015
Status Published
Journal Frontiers in neural circuits
Year 2015
Date Published
Volume : Pages 9 : 36
PubMed Reference 26257608
Abstract Commissural neurons project across the midline at all levels of the central
nervous system (CNS), providing bilateral communication critical for the
coordination of motor activity and sensory perception. Midline crossing at the
spinal ventral midline has been extensively studied and has revealed that
multiple developmental lineages contribute to this commissural neuron
population. Ventral midline crossing occurs in a manner dependent on Robo3
regulation of Robo/Slit signaling and the ventral commissure is absent in the
spinal cord and hindbrain of Robo3 mutants. Midline crossing in the spinal cord
is not limited to the ventral midline, however. While prior anatomical studies
provide evidence that commissural axons also cross the midline dorsally, little
is known of the genetic and molecular properties of dorsally-crossing neurons or
of the mechanisms that regulate dorsal midline crossing. In this study, we
describe a commissural neuron population that crosses the spinal dorsal midline
during the last quarter of embryogenesis in discrete fiber bundles present
throughout the rostrocaudal extent of the spinal cord. Using
immunohistochemistry, neurotracing, and mouse genetics, we show that this
commissural neuron population includes spinal inhibitory neurons and sensory
nociceptors. While the floor plate and roof plate are dispensable for dorsal
midline crossing, we show that this population depends on Robo/Slit signaling
yet crosses the dorsal midline in a Robo3-independent manner. The
dorsally-crossing commissural neuron population we describe suggests a substrate
circuitry for pain processing in the dorsal spinal cord.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.