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Publication
Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK
Phosphatase 5.
Authors Zhang Y, Nguyen T, Tang P, Kennedy NJ, Jiao H, Zhang M, Reynolds JM, Jaeschke A,
Martin-Orozco N, Chung Y, He WM, Wang C, Jia W, Ge B, Davis RJ, Flavell RA, Dong
C
Submitted By Submitted Externally on 8/16/2017
Status Published
Journal The Journal of biological chemistry
Year 2015
Date Published 6/12/2015
Volume : Pages 290 : 14875 - 83
PubMed Reference 25922079
Abstract Obesity and metabolic disorders such as insulin resistance and type 2 diabetes
have become a major threat to public health globally. The mechanisms that lead
to insulin resistance in type 2 diabetes have not been well understood. In this
study, we show that mice deficient in MAPK phosphatase 5 (MKP5) develop insulin
resistance spontaneously at an early stage of life and glucose intolerance at a
later age. Increased macrophage infiltration in white adipose tissue of young
MKP5-deficient mice correlates with the development of insulin resistance.
Glucose intolerance in MKP5-deficient mice is accompanied by significantly
increased visceral adipose weight, reduced AKT activation, enhanced p38
activity, and increased inflammation in visceral adipose tissue when compared
with wild-type (WT) mice. Deficiency of MKP5 resulted in increased inflammatory
activation in macrophages. These findings thus demonstrate that MKP5 critically
controls inflammation in white adipose tissue and the development of metabolic
disorders.




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