mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Recovery of Vocal Fold Epithelium after Acute Phonotrauma.
Authors Rousseau B, Kojima T, Novaleski CK, Kimball EE, Valenzuela CV, Mizuta M, Daniero
JJ, Garrett CG, Sivasankar MP
Submitted By Submitted Externally on 8/17/2017
Status Published
Journal Cells, tissues, organs
Year 2017
Date Published
Volume : Pages 204 : 93 - 104
PubMed Reference 28647731
Abstract We investigated the timeline of tissue repair of vocal fold epithelium after
acute vibration exposure using an in vivo rabbit model. Sixty-five New Zealand
white breeder rabbits were randomized to 120 min of modal- or raised-intensity
phonation. After the larynges were harvested at 0, 4, 8, and 24 h, and at 3 and
7 days, the vocal fold tissue was evaluated using electron microscopy and
quantitative real-time polymerase chain reaction. There was an immediate
decrease in the microprojection depth and height following raised-intensity
phonation, paired with upregulation of cyclooxygenase-2. This initial 24-h
period was also characterized by the significant downregulation of junction
proteins. Interleukin 1ß and transforming growth factor ß1 were upregulated for
3 and 7 days, respectively, followed by an increase in epithelial cell surface
depth at 3 and 7 days. These data appear to demonstrate a shift from
inflammatory response to the initiation of a restorative process in the vocal
fold epithelium between 24 h and 3 days. Despite the initial damage from
raised-intensity phonation, the vocal fold epithelium demonstrates a remarkable
capacity for the expeditious recovery of structural changes from transient
episodes of acute phonotrauma. While structurally intact, the return of
functional barrier integrity may be delayed by repeated episodes of phonotrauma
and may also play an important role in the pathophysiology of vocal fold
lesions.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.