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Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male
Harvey I, Stephenson EJ, Redd JR, Tran QT, Hochberg I, Qi N, Bridges D
Dave Bridges on 4/24/2018
Volume : Pages
159 : 2275 - 2287
The purpose of this study was to determine the effects of glucocorticoid-induced
metabolic dysfunction in the presence of diet-induced obesity. C57BL/6J adult
male lean and diet-induced obese mice were given dexamethasone, and levels of
hepatic steatosis, insulin resistance, and lipolysis were determined. Obese mice
given dexamethasone had significant, synergistic effects on fasting glucose,
insulin resistance, and markers of lipolysis, as well as hepatic steatosis. This
was associated with synergistic transactivation of the lipolytic enzyme adipose
triglyceride lipase. The combination of chronically elevated glucocorticoids and
obesity leads to exacerbations in metabolic dysfunction. Our findings suggest
lipolysis may be a key player in glucocorticoid-induced insulin resistance and
fatty liver in individuals with obesity.
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