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Publication
The effect of Mono- and Diglycerides on the Digestion and Absorption of Lutein
in Lymph Fistula Rats.
Authors Tso P, Vurma M, Ko CW, Lee DM, DeMichele S
Submitted By Submitted Externally on 4/24/2018
Status Published
Journal American journal of physiology. Gastrointestinal and liver physiology
Year 2018
Date Published 2/1/2018
Volume : Pages Not Specified : Not Specified
PubMed Reference 29470144
Abstract Breastmilk lutein is better absorbed by infants than lutein delivered in infant
formula. Therefore, we wish to better understand the possible absorption
differences of lutein in breast milk versus infant formula by determining its
bioavailability after gastric administration and whether the intestinal
absorption of lutein can be improved by using new delivery vehicles. STUDY ONE
compared the intestinal uptake, and the lymphatic and portal transport of lutein
in conscious lymph fistula rats. Four groups of lymph and portal vein cannulated
rats (n = 8-10/group) were randomized to receive via the gastric tube increasing
doses (10,20,40,or 80mg/kg) of 20% lutein in safflower oil (SO) suspension to
assess whether there was a saturable level of lutein that can be absorbed and
transported in lymph. Aliquots of hourly portal blood and lymph were taken for
lutein analysis. The dose response study showed that 20 mg/kg lutein was the
saturable level of lymphatic lutein absorption with no lutein detected in portal
circulation at any dosage level tested. STUDY TWO randomized five groups of
lymph fistula rats (n = 4-9/group) to receive 20 mg/kg lutein from either lutein
in SO or from lutein in four different mono- and diglyceride oil mixtures (MDG).
Gastric infusion of lutein suspended in MDG (20 mg/kg) significantly improved
(71% - 211%; p<0.05) lymphatic lutein output 2-6 hours after lipid feeding
versus lutein in SO. We conclude that a mixture of MDG helps solubilize lutein
and facilitate gastrointestinal micelle formation thus improving lymphatic
lutein absorption compared to triglyceride oils.




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