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Publication
Meta-fibrosis links positive energy balance and mitochondrial metabolism to
insulin resistance.
Authors Lark DS, Wasserman DH
Submitted By Submitted Externally on 4/24/2018
Status Published
Journal F1000Research
Year 2017
Date Published
Volume : Pages 6 : 1758
PubMed Reference 29043068
Abstract Obesity and insulin resistance often emerge from positive energy balance and
generally are linked to low-grade inflammation. This low-grade inflammation has
been called "meta-inflammation" because it is a consequence of the metabolic
dysregulation that can accompany overnutrition. One means by which
meta-inflammation is linked to insulin resistance is extracellular matrix
expansion secondary to meta-inflammation, which we define here as
"meta-fibrosis". The significance of meta-fibrosis is that it reflects a
situation in which the extracellular matrix functions as a multi-level
integrator of local (for example, mitochondrial reactive oxygen species
production) and systemic (for example, inflammation) inputs that couple to
cellular processes creating insulin resistance. While adipose tissue
extracellular matrix remodeling has received considerable attention, it is
becoming increasingly apparent that liver and skeletal muscle extracellular
matrix remodeling also contributes to insulin resistance. In this review, we
address recent advances in our understanding of energy balance, mitochondrial
energetics, meta-inflammation, and meta-fibrosis in the development of insulin
resistance.




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