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Publication
CalR: A Web-Based Analysis Tool for Indirect Calorimetry Experiments.
Authors Mina AI, LeClair RA, LeClair KB, Cohen DE, Lantier L, Banks AS
Submitted By Submitted Externally on 8/20/2018
Status Published
Journal Cell Metabolism
Year 2018
Date Published 7/1/2018
Volume : Pages Not Specified : Not Specified
PubMed Reference 30017358
Abstract We report a web-based tool for analysis of experiments using indirect
calorimetry to measure physiological energy balance. CalR simplifies the process
to import raw data files, generate plots, and determine the most appropriate
statistical tests for interpretation. Analysis using the generalized linear
model (which includes ANOVA and ANCOVA) allows for flexibility in interpreting
diverse experimental designs, including those of obesity and thermogenesis.
Users also may produce standardized output files for an experiment that can be
shared and subsequently re-evaluated using CalR. This framework will provide the
transparency necessary to enhance consistency, rigor, and reproducibility. The
CalR analysis software will greatly increase the speed and efficiency with which
metabolic experiments can be organized, analyzed per accepted norms, and
reproduced and will likely become a standard tool for the field. CalR is
accessible at https://CalRapp.org/.




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