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Publication
Resorbable Nanocomposites with Bone-Like Strength and Enhanced Cellular
Activity.
Authors Lu S, McEnery MAP, Rogers BR, Wenke JC, Shimko D, Guelcher SA
Submitted By Submitted Externally on 8/20/2018
Status Published
Journal Journal of materials chemistry. B
Year 2017
Date Published 6/1/2017
Volume : Pages 5 : 4198 - 4206
PubMed Reference 30101031
Abstract Bone cements for treatment of fractures at weight-bearing sites are subjected to
dynamic physiological loading from daily activities. An ideal bone cement
rapidly sets after injection, exhibits bone-like strength, stimulates osteogenic
differentiation of endogenous cells, and resorbs at a rate aligned with patient
biology. However, currently available materials fall short of these targeted
properties. Nanocrystalline hydroxyapatite (nHA) enhances osteogenic
differentiation, new bone formation, and osteoclast differentiation activity
compared to amorphous or micron-scale crystalline hydroxyapatite. However, the
brittle mechanical properties of nHA precludes its use in treatment of
weight-bearing bone defects. In this study, we report settable nHA-poly(ester
urethane) (PEUR) nanocomposites synthesized from nHA, lysine triisocyanate
(LTI), and poly(caprolactone) triol via a solvent-free process. The
nanocomposites are easily mixed and injected using a double-barrel syringe,
exhibit mechanical properties exceeding those of conventional bone cements,
enhance mineralization of osteoprogenitor cells in vitro, and undergo
osteoclast-mediated degradation in vitro. This combination of properties cannot
be achieved using other technologies, which underscores the potential of
nHA-PEUR nanocomposites as a new approach for promoting bone healing at
weight-bearing sites.




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