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Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection against
Atherosclerosis and Diabetes.
Qu J, Ko CW, Tso P, Bhargava A
Submitted Externally on 4/15/2019
Volume : Pages
Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily
synthesized in the small intestine, packaged into chylomicrons, and secreted
into intestinal lymph during fat absorption. In the circulation, apoA-IV is
present on chylomicron remnants, high-density lipoproteins, and also in
lipid-free form. ApoA-IV is involved in a myriad of physiological processes such
as lipid absorption and metabolism, anti-atherosclerosis, platelet aggregation
and thrombosis, glucose homeostasis, and food intake. ApoA-IV deficiency is
associated with atherosclerosis and diabetes, which renders it as a potential
therapeutic target for treatment of these diseases. While much has been learned
about the physiological functions of apoA-IV using rodent models, the action of
apoA-IV at the cellular and molecular levels is less understood, let alone
apoA-IV-interacting partners. In this review, we will summarize the findings on
the molecular function of apoA-IV and apoA-IV-interacting proteins. The
information will shed light on the discovery of apoA-IV receptors and the
understanding of the molecular mechanism underlying its mode of action.
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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