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Publication
Glucose and GLP-2 (Glucagon-Like Peptide-2) Mobilize Intestinal Triglyceride by
Distinct Mechanisms.
Authors Stahel P, Xiao C, Davis X, Tso P, Lewis GF
Submitted By Submitted Externally on 8/6/2019
Status Published
Journal Arteriosclerosis, thrombosis, and vascular biology
Year 2019
Date Published 8/1/2019
Volume : Pages 39 : 1565 - 1573
PubMed Reference 31294621
Abstract Dietary triglycerides are partially retained in the intestine within
intracellular or extracellular compartments, which can be rapidly mobilized in
response to several stimuli, including glucose and GLP-2 (glucagon-like
peptide-2). To elucidate the mechanism of intestinal lipid mobilization, this
study examined the patterns and time course of lymph flow and triglycerides
after glucose and GLP-2 treatment in rats. Approach and Results: Lymph flow,
triglyceride concentration, and triglyceride output were assessed in mesenteric
lymph duct-cannulated rats in response to an intraduodenal (i.d.) lipid bolus
followed 5 hours later by either (1) i.d. saline+intraperitoneal (i.p.) saline
(placebo), (2) i.d. glucose plus i.p. saline, (3) i.d. saline+i.p. GLP-2, or (4)
i.d. glucose+i.p. GLP-2. GLP-2 and glucose administered alone or in combination
stimulated total triglyceride output to a similar extent, but the timing and
pattern of stimulation differed markedly. Whereas GLP-2 rapidly increased lymph
flow with no effect on lymph triglyceride concentration or triglyceride:apoB48
(apolipoprotein B48) ratio (a surrogate marker of chylomicron size) compared
with placebo, glucose transiently decreased lymph flow followed by delayed
stimulation of lymph flow and increased lymph triglyceride concentration and
triglyceride:apoB48 ratio., Glucose and GLP-2 robustly enhanced intestinal
triglyceride output in rats but with different effects on lymph flow, lymph
triglyceride concentration, and chylomicron size. GLP-2 stimulated triglyceride
output primarily by enhancing lymph flow with no effect on chylomicron size,
whereas glucose mobilized intestinal triglycerides, stimulating secretion of
larger chylomicrons. This suggests that these 2 stimuli mobilize intestinal
lipid by different mechanisms.





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