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Nutrient and hormone composition of milk is altered in rodent dams
post-bariatric surgery.
Authors Deer EM, Welch B, Hernandez LL, Seeley RJ, Grayson BE
Submitted By Submitted Externally on 1/14/2020
Status Published
Journal Journal of developmental origins of health and disease
Year 2020
Date Published 2/1/2020
Volume : Pages 11 : 71 - 77
PubMed Reference 31397254
Abstract Although bariatric surgery is approved for a woman of child-bearing age with an
interest in subsequent pregnancy, reports of in utero growth issues during
pregnancy have garnered a closer look at the impact of maternal surgical weight
loss on the pre- and postpartum periods. Offspring of dams having received
vertical sleeve gastrectomy (VSG) are born small-for-gestational age and have
increased risk for metabolic syndrome later in life. Here, we aimed to determine
whether the postnatal catch-up growth trajectory of bariatric offspring may be
affected by milk composition. Milk samples were collected at postnatal day 15/16
from dams having received VSG surgery and fed a high-fat diet (HFD) (H-VSG),
Sham surgery and fed chow (C-Sham), or Sham surgery and fed HFD (H-Sham). Milk
obtained from H-VSG dams had elevated glucose (P < 0.05) and significantly
reduced triglyceride content (P < 0.01). Milk from H-Sham dams had the lowest
amount of milk protein (P < 0.05). Fatty acid composition measured by
fractionation was largely not affected by surgery but rather maternal diet. No
difference was observed in milk leptin levels; however, insulin, adiponectin,
and growth hormone levels were significantly increased in milk from H-VSG
animals. H-Sham had the lowest level of immunoglobulin (Ig)A, whereas IgG was
significantly reduced in H-VSG. Taken together, the quality of milk from H-VSG
dams suggests that milk composition could be a factor in reducing the rate of
growth during the lactation period.


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