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Publication
Consuming cholera toxin counteracts age-associated obesity.
Authors Varian BJ, Poutahidis T, Haner G, Hardas A, Lau V, Erdman SE
Submitted By Susan Erdman on 2/27/2020
Status Published
Journal Oncotarget
Year 2019
Date Published 9/17/2019
Volume : Pages 10 : 5497 - 5509
PubMed Reference 31565184
Abstract During the past forty years there has been an inexplicable increase in chronic
inflammatory disorders, including obesity. One theory, the 'hygiene hypothesis',
involves dysregulated immunity arising after too few beneficial early life
microbe exposures. Indeed, earlier studies have shown that gut microbe-immune
interactions contribute to smoldering inflammation, adiposity, and weight gain.
Here we tested a safe and well-established microbe-based immune adjuvant to
restore immune homeostasis and counteract inflammation-associated obesity in
animal models. We found that consuming Vibrio cholerae exotoxin subunit B (ctB)
was sufficient to inhibit age-associated obesogenic outcomes in wild type mice,
including reduced crown-like structures (CLS) and granulomatous necrosis
histopathology in fat depots. Administration of cholera toxin reduced weight
gain irrespective of age during administration; however, exposure during youth
imparted greater slenderizing effects when compared with animals receiving ctB
for the first time during adulthood. Beneficial effects were transplantable to
other obesity-prone animals using immune cells alone, demonstrating an
immune-mediated mechanism. Taken together, we concluded that oral vaccination
with cholera toxin B helps stimulate health-protective immune responses that
counteract age-associated obesity.




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