mmpc-logo
twitter-logo @NationalMMPC
| Create Account | login
Publication
Adipose tissue macrophages: Unique polarization and bioenergetics in obesity.
Authors Caslin HL, Bhanot M, Bolus WR, Hasty AH
Submitted By Submitted Externally on 4/6/2020
Status Published
Journal Immunological reviews, REFERENCES
Year 2020
Date Published 4/1/2020
Volume : Pages Not Specified : Not Specified
PubMed Reference 32237081
Abstract Macrophages comprise a majority of the resident immune cells in adipose tissue
(AT) and regulate both tissue homeostasis in the lean state and metabolic
dysregulation in obesity. Since the AT environment rapidly changes based upon
systemic energy status, AT macrophages (ATMs) must adapt phenotypically and
metabolically. There is a distinct dichotomy in the polarization and
bioenergetics of in vitro models, with M2 macrophages utilizing oxidative
phosphorylation (OX PHOS) and M1 macrophages utilizing glycolysis. Early studies
suggested differential polarization of ATMs, with M2-like macrophages
predominant in lean AT and M1-like macrophages in obese AT. However, recent
studies show that the phenotypic plasticity of ATMs is far more complicated,
which is also reflected in their bioenergetics. Multiple ATM populations exist
along the M2 to M1 continuum and appear to utilize both glycolysis and OX PHOS
in obesity. The significance of the dual fuel bioenergetics is unclear and may
be related to an intermediate polarization, their buffering capacity, or the
result of a mixed population of distinct polarized ATMs. Recent evidence also
suggests that ATMs of lean mice serve as a substrate buffer or reservoir to
modulate lipid, catecholamine, and iron availability. Furthermore, recent models
of weight loss and weight cycling reveal additional roles for ATMs in systemic
metabolism. Evaluating ATM phenotype and intracellular metabolism together may
more accurately illuminate the consequences of ATM accumulation in obese AT,
lending further insight into obesity-related comorbidities in humans.





Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.