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Publication
Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT)
Produce Positive Effects on Mood and Anxiety in Rodents.
Authors Cameron LP, Benson CJ, DeFelice BC, Fiehn O, Olson DE
Submitted By Submitted Externally on 4/30/2020
Status Published
Journal ACS chemical neuroscience
Year 2019
Date Published 7/1/2019
Volume : Pages 10 : 3261 - 3270
PubMed Reference 30829033
Abstract Drugs capable of ameliorating symptoms of depression and anxiety while also
improving cognitive function and sociability are highly desirable. Anecdotal
reports have suggested that serotonergic psychedelics administered in low doses
on a chronic, intermittent schedule, so-called "microdosing", might produce
beneficial effects on mood, anxiety, cognition, and social interaction. Here, we
test this hypothesis by subjecting male and female Sprague Dawley rats to
behavioral testing following the chronic, intermittent administration of low
doses of the psychedelic N,N-dimethyltryptamine (DMT). The behavioral and
cellular effects of this dosing regimen were distinct from those induced
following a single high dose of the drug. We found that chronic, intermittent,
low doses of DMT produced an antidepressant-like phenotype and enhanced fear
extinction learning without impacting working memory or social interaction.
Additionally, male rats treated with DMT on this schedule gained a significant
amount of body weight during the course of the study. Taken together, our
results suggest that psychedelic microdosing may alleviate symptoms of mood and
anxiety disorders, though the potential hazards of this practice warrant further
investigation.




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