mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Papillary thyroid carcinoma behavior: clues in the tumor microenvironment.
Authors Bergdorf K, Ferguson DC, Mehrad M, Ely K, Stricker T, Weiss VL
Submitted By Submitted Externally on 9/28/2020
Status Published
Journal Endocrine-related cancer
Year 2019
Date Published 6/1/2019
Volume : Pages 26 : 601 - 614
PubMed Reference 30965283
Abstract The prevalence of thyroid carcinoma is increasing and represents the most common
endocrine malignancy, with papillary thyroid carcinoma (PTC) being the most
frequent subtype. The genetic alterations identified in PTCs fail to distinguish
tumors with different clinical behaviors, such as extra-thyroidal extension and
lymph node metastasis. We hypothesize that the immune microenvironment may play
a critical role in tumor invasion and metastasis. Computational immunogenomic
analysis was performed on 568 PTC samples in The Cancer Genome Atlas using
CIBERSORT, TIMER and TIDE deconvolution analytic tools for characterizing immune
cell composition. Immune cell infiltrates were correlated with histologic type,
mutational type, tumor pathologic T stage and lymph node N stage. Dendritic
cells (DCs) are highly associated with more locally advanced tumor T stage
(T3/T4, odds ratio (OR) = 2.6, CI = 1.4-4.5, P = 5.4 × 10-4). Increased
dendritic cells (OR = 3.4, CI = 1.9-6.3, P = 5.5 × 10-5) and neutrophils (OR =
10.5, CI = 2.7-44, P = 8.7 × 10-4) significantly correlate with lymph node
metastasis. In addition, dendritic cells positively correlate with tall cell
morphology (OR = 4.5, CI = 1.6-13, P = 4.9 × 10-3) and neutrophils negatively
correlate with follicular morphology (OR = 1.3 × 10-3, CI = 5.3 × 10-5-0.031, P
= 4.1 × 10-5). TIDE analysis indicates an immune-exclusive phenotype that may be
mediated by increased galectin-3 found in PTCs. Thus, characterization of the
PTC immune microenvironment using three computational platforms shows that
specific immune cells correlate with mutational type, histologic type, local
tumor extent and lymph node metastasis. Immunologic evaluation of PTCs may
provide a better indication of biologic behavior, resulting in the improved
diagnosis and treatment of thyroid cancer.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.