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Publication
Maternal High-Fat-High-Carbohydrate Diet-Induced Obesity Is Associated with
Increased Appetite in Peripubertal Male but Not Female C57Bl/6J Mice.
Authors Kulhanek D, Weigel R, Paulsen ME
Submitted By Submitted Externally on 11/10/2020
Status Published
Journal Nutrients
Year 2020
Date Published 9/1/2020
Volume : Pages 12 : Not Specified
PubMed Reference 32987812
Abstract Diet-induced maternal obesity might play a critical role in altering
hypothalamic development, predisposing the offspring to obesity and metabolic
disease later in life. The objective of this study was to describe both
phenotypic and molecular sex differences in peripubertal offspring energy
homeostasis, using a mouse model of maternal obesity induced by a
high-fat-high-carbohydrate (HFHC) diet. We report that males, not females,
exposed to a maternal HFHC diet had increased energy intake. Males exposed to a
maternal HFHC diet had a 15% increased meal size and a 46% increased frequency,
compared to the control (CON) males, without a change in energy expenditure. CON
and HFHC offspring did not differ in body weight, composition, or plasma
metabolic profile. HFHC diet caused decreased hypothalamic glucocorticoid
expression, which was further decreased in males compared to females. Maternal
weight, maternal caloric intake, and male offspring meal frequency were
inversely correlated with offspring hypothalamic insulin receptor (IR)
expression. There was a significant interaction between maternal-diet exposure
and sex in hypothalamic IR. Based on our preclinical data, we suggest that
interventions focusing on normalizing maternal nutrition might be considered to
attenuate nutritional influences on obesity programming and curb the continuing
rise in obesity rates.




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