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Guidelines & Policies
The MMPC is sponsored by the National Institutes of Health as a resource to provide services to the community of scientists who use mice to study diabetes, obesity, diabetic complications, and other metabolic diseases. In order to accomplish this goal, the MMPC offers to researchers phenotyping tests that require specialized expertise or equipment. Modest fees for these test are set at or below actual cost. Researchers can arrange to ship mice or murine tissues to the Centers for analysis.
  1. Center Structure & Steering Committees
  2. Application for Services
  3. Data
  4. Data Ownership
  5. Fees
  6. Animal Guidelines
  7. Animal Quarantine Procedures
  8. Acknowledgements

Center Structure & Steering Committees
Each Center has a structure that consists of an Executive Committee, an Administrative Core and Director, experimental and analytical Test Cores, an Animal Health and Welfare Core, and a Research & Development program. The MMPC program has a Coordinating and Bioinformatics Unit which houses the MMPC Pilot and Feasibility grant program, the MMPC website, and MMPC Database. This CBU is shared with the NIH-sponsored Diabetes Complications Consortium (DiaComp). Details for the structure and personnel at each MMPC can be obtained from the individual web sites. The six Centers share a National Steering Committee consisting of Center Directors, NIH personnel, and external advisors.

Application for Services
After identifying the appropriate Center(s) from the individual web pages or test catalog the applicant should first contact the Center Director or Core Director to discuss the mouse strain, determine the best set of tests to be conducted, and obtain an estimate of costs. The applicant then obtains a password protected account and completes an online request for services which is targeted to the appropriate Center. The request is reviewed by the Center Executive Committee. Acceptance is based on Center workload, relevance of the available and/or requested tests to the mouse model, and the perceived value of the animal to diabetes, obesity, and metabolic disease research. The applicant will be contacted with the decision. Following consultation with the Center and/or Core Director(s), a written estimate for all tests agreed upon, including the number of mice required for each test and a timeline for receipt and testing of the mice at the MMPC, will be sent to the applicant for his/her approval.

Data
Tests will be conducted using the experimental protocols found on the individual MMPC web sites or in the catalog. Detailed descriptions will be provided upon request. Upon completion of the requested tests, data in an appropriate form will be stored in the MMPC database and posted on MMPC's password protected web site for viewing by the submitting investigator only. The Center personnel will be available to discuss experimental details, etc.

Data Ownership
All data generated from a submitted strain belongs to the submitting investigator and his/her institution.
Center personnel have no rights to use this data for personal or institutional research purposes unless a formal, documented arrangement of collaboration exists between Center personnel and the investigator.
The NIH strongly encourages the sharing of research data. NIH guidelines regarding data sharing can be found at http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-03-032.html. This notice states,
We believe that data sharing is essential for expedited translation of research results into knowledge, products, and procedures to improve human health. The NIH endorses the sharing of final research data to serve these and other important scientific goals. The NIH expects and supports the timely release and sharing of final research data from NIH-supported studies for use by other researchers… [The] definition of "the timely release and sharing" [is] to be no later than the acceptance for publication of the main findings from the final data set. NIH continues to expect that the initial investigators may benefit from first and continuing use but not from prolonged exclusive use.
All data collected at the Centers from background strains and standard disease models (i.e., those commercially available) will be stored in the publicly available MMPC database. It is anticipated that the complete set of data generated by the MMPCs on all newly generated strains, taken together in a database, will be valuable for understanding diabetes, obesity and other metabolic diseases.
Therefore, the NIDDK requests that investigators allow the data generated by an MMPC to be placed in a public MMPC database after the first of the following two conditions has been met:

  1. The data have been published and are therefore in the public domain.
  2. Two years have passed since the investigator received the data from the Center.
Because it is sometimes not possible to publish or even interpret data within a two-year timeframe, investigators may request that specific data be withheld from the public database for an additional period of time.
The Center personnel and the investigator must read and sign a Mouse / Tissue Transfer Agreement, which clearly states these rights and responsibilities.

Fees
Price information for each test is available on the individual Center web pages or by request from each MMPC. Applicants will receive a written estimate that must be acknowledged by the submitting investigator before animals can be shipped for testing. Fees are set as a fraction of the total costs incurred by the MMPC for that test, and are calculated based on the obtainment of revenue neutrality.

Animal Guidelines
Please see animal care, shipping & handling guidelines. Specific instructions can be obtained from center personnel.

Animal Quarantine Procedures
It is in the interest of the receiving MMPC institution to have a relatively short quarantine period so mice can be studied as soon after receipt as possible to avoid aging effects and to avoid extra per diem costs while mice are held in quarantine. The recommendations outlined below were developed in 2010 by an adhoc committee of experts enlisted by the MMPC consortium to devise a standardized approach to accelerate quarantine periods (3-4 weeks) while minimizing the risks of pathogens being introduced into the receiving MMPC.


Acknowledgements
One index of success of the NIDDK MMPC program is the contribution of data produced by the MMPC to publications and oral communications. Please acknowledge the MMPC when presenting data obtained using Center Services.
Case Western Reserve University MMPC is supported by U24 DK076174
University of California - Davis (UC Davis) MMPC is supported by U24 DK092993
University of Cincinnati Medical Center MMPC is supported by U24 DK059630
University of Massachusetts (UMass) MMPC is supported by U24 DK093000
Vanderbilt University School of Medicine MMPC is supported by U24 DK059637
Yale University School of Medicine MMPC is supported by U24 DK059635