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Publication
Low docosahexaenoic acid status is associated with reduced indices in cortical
integrity in the anterior cingulate of healthy male children: A (1)H MRS Study.
Authors McNamara RK, Jandacek R, Tso P, Weber W, Chu WJ, Strakowski SM, Adler CM,
Delbello MP
Submitted By Patrick Tso on 5/13/2013
Status Published
Journal Nutritional neuroscience
Year 2013
Date Published 5/1/2013
Volume : Pages 16 : 183 - 190
PubMed Reference 23582513
Abstract Docosahexaenoic acid (DHA, 22:6n-3) is the principal omega-3 fatty acid in
mammalian brain gray matter, and emerging preclinical evidence suggests that DHA
has neurotrophic and neuroprotective properties. This study investigated
relationships among DHA status, neurocognitive performance, and cortical
metabolism measured with proton magnetic resonance spectroscopy ((1)H MRS) in
healthy developing male children (aged 8-10 years, n = 38). Subjects were
segregated into low-DHA (n = 19) and high-DHA (n = 19) status groups by a median
split of erythrocyte DHA levels. Group differences in (1)H MRS indices of
cortical metabolism, including choline (Cho), creatine (Cr), glutamine +
glutamate + ?-aminobutyric acid (Glx), myo-inositol (mI), and n-acetyl aspartate
(NAA), were determined in the right and left dorsolateral prefrontal cortex
(R/L-DLPFC, BA9) and bilateral anterior cingulate cortex (ACC, BA32/33). Group
differences in neurocognitive performance were evaluated with the Kaufman Brief
Intelligence Test and identical-pairs version of the continuous performance task
(CPT-IP). Subjects in the low-DHA group consumed fish less frequently (P =
0.02), had slower reaction times on the CPT-IP (P = 0.007), and exhibited lower
mI (P = 0.007), NAA (P = 0.007), Cho (P = 0.009), and Cr (P = 0.01)
concentrations in the ACC compared with the high-DHA group. There were no group
differences in ACC Glx or any metabolite in the L-DLPFC and R-DLPFC. These data
indicate that low-DHA status is associated with reduced indices of metabolic
function in the ACC and slower reaction time during sustained attention in
developing male children.




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