| Create Account | login

login

MICROMouse Program Application Abstract

MMPC Funded Abstracts

Funding Programs

Increased risk for diabetes and obesity in offspring of multiparous mice

Laura Woollett (Cincinnati, OH)

MICROMouse Program

Large-for-gestationally aged (LGA) infants are at an increased risk to develop diabetes and obesity later in life in both humans and rodents. The accelerated fetal growth rates appear to permanently affect metabolic pathways (programming), thereby increasing the susceptibility of the individual to develop diabetes and obesity in adulthood. We have recently determined in mice, as in humans, that fetal growth rates are accelerated in later pregnancies of multiparous dams of the FVBN and C57BL/6 strains. We hypothesize the LGA pups (from the fourth pregnancies) will be prone to develop diabetes and obesity in adulthood as compared to average-sized pups (from the first pregnancies). If our hypothesis tests true, then the development of diabetes and obesity in some mice would be due to fetal programming as well as the genetic manipulation being examined. Since most mouse colonies are maintained by breeder mice that are bred multiple times, this could be a major confounding factor of studies intended to examine development of obesity and diabetes. Thus, the aim of this proposal is to determine if larger pups born from later (e.g. fourth) pregnancies have a greater tendency to develop diabetes and obesity than pups born from first pregnancies. We will determine if this tendency is the same for FVBN and C57BL/6 mouse strains, strains with different propensities to develop obesity and diabetes. We will also begin to dissect the mechanism responsible for the changes in growth rates by delineating changes in transport of metabolites from the maternal circulation to the fetus. Knowing if LGA pups from later pregnancies of multiparous dams develop diabetes and obesity more readily is essential for the MMPC Program and could fundamentally alter how investigators interpret data and design studies. In addition, dissecting out the mechanism responsible for the different fetal growth rates will enable researchers to begin to design strategies aimed at breaking the obesity cycle.

Back to Top

Store Credentials?

MMPC-Live web resource – Terms of Use

Warranty disclaimer and copyright notice

THE MMPC-Live MAKES NO REPRESENTATION ABOUT THE SUITABILITY OR ACCURACY OF THE SOFTWARE OR DATA FOR ANY PURPOSE, AND MAKES NO WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR THAT THE USE OF THE SOFTWARE OR DATA WILL NOT INFRINGE ANY THIRD PARTY PATENTS, COPYRIGHTS, TRADEMARKS, OR OTHER RIGHTS. THE SOFTWARE AND DATA ARE PROVIDED "AS IS".

The Mouse Metabolic Phenotyping Centers (MMPC-Live) is an NIDDK funded consortium and adheres to the NIH Data Sharing Policy.

MMPC-Live clients make their data freely available whereby MMPC-Live users may freely build upon, enhance and reuse those data for any purpose without restriction. Scholarly citation norms must be followed for content reuse. Please acknowledge the MMPC-Live using the following text: 'The MMPC-Live data used in this manuscript was supported by the NIDDK National Mouse Metabolic Phenotyping Centers (MMPC-Live, RRID:SCR_008997, www.mmpc.org)'. To cite specific MMPC-Live centers, please use the appropriate RRID available from the MMPC-Live website (https://www.mmpc.org/shared/centers.aspx).

Please note that the acknowledgment text includes a Research Resource Identifier (RRID) for the MMPC-Live CU and Centers. Reproducibility is one of the corner stones of effective, open and transparent biomedical published research. However, too often, resources (e.g. model organisms, antibodies, and tools) are not reported with adequate detail to ensure others can replicate or expand upon the published results. The Research Resource Identification Initiative (#RII) seeks to change these limitations in reporting by the use of unique Research Resource Identifiers (RRIDs). This initiative is designed to encourage authors to provide identification of the types of resources used in their research by adding a globally unique accession number to the resources described in the their manuscripts. These identifiers, called RRIDs, will allow authors to cite the resources that they use in their manuscripts. RRIDs allow for easy tracking of all papers that have used the same resource making it easy to access how the same resources works in other scenarios.

It is expected that MMPC-Live users follow scholarly citation norms, giving credit to fellow scholars when accessing/using protocols and data, including data derived by MMPC-Live (such as summary data) and any plots, tables or screenshots depicting those data.

It is possible for invalid or incomplete results to be presented on the MMPC-Live web site due to software bugs, data problems, or artifacts of human error. Data sets are not necessarily static; we reserve the right to post corrections and updates as needed.

Prohibited use. Data contributors and data users may not use MMPC-Live in any unlawful manner, or in any manner that could impair MMPC-Live services, security or functionality. Automated usage (webcrawlers and similar) must observe each page's "meta robots" html tags and space requests by ≥ 2 seconds. We reserve the right to block any IP associated with what we consider to be excessive or abusive usage patterns, and/or to take any action we deem necessary.

MMPC-Live is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Menu

Home

Contact

About MMPC

Animal Husbandry

Tests Data

Search Data

Analysis

Clients

MMPC Centers

Newsletter

Interested in receiving MMPC News?

Mouse Phenotyping
@NationalMMPC

2017 National MMPC. All Rights Reserved.