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Publication
Glucose phosphorylation as a barrier to muscle glucose uptake.
Authors Fueger PT
Submitted By David Wasserman on 11/6/2007
Status Published
Journal Clinical and experimental pharmacology & physiology
Year 2005
Date Published 4/1/2005
Volume : Pages 32 : 314 - 318
PubMed Reference 15810998
Abstract 1. Glucose phosphorylation is the first irreversible step of the muscle glucose
uptake pathway and is catalysed by a hexokinase isozyme. 2. While glucose
transport is the primary barrier to muscle glucose uptake during basal
conditions, glucose phosphorylation becomes an important barrier to muscle
glucose uptake during stimulated conditions such as hyperinsulinaemia or
exercise. 3. High fat feeding markedly impairs insulin- and exercise-stimulated
muscle glucose uptake. As hexokinase II overexpression corrects this
dietary-induced deficit during exercise, glucose phosphorylation is a site of
impairment following high fat feeding. 4. Exercise is an important tool for
diagnosing deficits in glucose phosphorylation.




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