mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Hormone-sensitive lipase knockout mice have increased hepatic insulin
sensitivity and are protected from short-term diet-induced insulin resistance in
skeletal muscle and heart.
Authors Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki
M, Shulman GI, Mitchell GA, Kim JK
Submitted By Jason Kim on 11/12/2007
Status Published
Journal American journal of physiology. Endocrinology and metabolism
Year 2005
Date Published
Volume : Pages 289 : E30 - E39
PubMed Reference 15701680
Abstract Insulin resistance in skeletal muscle and heart plays a major role in the
development of type 2 diabetes and diabetic heart failure and may be causally
associated with altered lipid metabolism. Hormone-sensitive lipase (HSL) is a
rate-determining enzyme in the hydrolysis of triglyceride in adipocytes, and
HSL-deficient mice have reduced circulating fatty acids and are resistant to
diet-induced obesity. To determine the metabolic role of HSL, we examined the
changes in tissue-specific insulin action and glucose metabolism in vivo during
hyperinsulinemic euglycemic clamps after 3 wk of high-fat or normal chow diet in
awake, HSL-deficient (HSL-KO) mice. On normal diet, HSL-KO mice showed a twofold
increase in hepatic insulin action but a 40% decrease in insulin-stimulated
cardiac glucose uptake compared with wild-type littermates. High-fat feeding
caused a similar increase in whole body fat mass in both groups of mice.
Insulin-stimulated glucose uptake was reduced by 50-80% in skeletal muscle and
heart of wild-type mice after high-fat feeding. In contrast, HSL-KO mice were
protected from diet-induced insulin resistance in skeletal muscle and heart, and
these effects were associated with reduced intramuscular triglyceride and fatty
acyl-CoA levels in the fat-fed HSL-KO mice. Overall, these findings demonstrate
the important role of HSL on skeletal muscle, heart, and liver glucose
metabolism.




Strains


Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.