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Strain
NU/J

Summary Data Summary
Official Name NU/J
Common Name Nude
Description The two main defects of mice homozygous for the nude
spontaneous mutation (Foxn1nu, formerly Hfh11nu) are
abnormal hair growth and defective development of the thymic
epithelium. Although the mice appear hairless, they are born
with functional but faulty hair growth follicles. Hair
growth cycles and patterns are evident especially in
pigmented mice but the faulty follicles do not allow the
hair to properly erupt. Homozygous pups can be identified as
young as 24 hours by their lack of whiskers or poorly
developed, crinkled whiskers. Nude mice are also athymic
caused by a developmental failure of the thymic anlage.
Consequently, homozygous nude mice lack T cells and suffer
from a lack of cell-mediated immunity. However there is not
a defect in T-cell precursors, and under the right
conditions some functional mature T cells can be found
especially in adult mice. Because of a defect in helper
T-cell activity, responses to thymus-dependent antigens when
detectable are primarily limited to IgM. Homozygous nude
mice show partial defect in B cell development probably due
to absence of functional T cells. Other endocrine and
neurological deficiencies have been reported. The use of
nude mice has reduced the number of thymectomy procedures
required in research projects. Homozygous nude females are
not effective breeders. Ovulation starts late at 2.5 months
and ends early at 4 months.
Development Status Not specified/Other
TypeCount
Investigators 1
Experiments 2


Investigators
NameInstitution
Jesika FaridiUniversity of the Pacific


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