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Strain
C57BL/6-Slc13a5tm1.2Helf

Summary Data Summary
Official Name C57BL/6-Slc13a5tm1.2Helf
Common Name INDY KO
Description A loxP site was inserted upstream of exon 1 and a loxP site
and FRT flanked neo cassette were inserted downstream of
exon 6 via homologous recombination. Flp mediated
recombination removed the neo cassette. Cre mediated
recombination removed exons 1 - 6. Analysis indicated the
liver mRNA expression is absent in homozygous mice.
Development Status Phenotyping ongoing
Creation Method recombinant congenic
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Andreas BirkenfeldYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Slc13a5knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.
Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI
Cell Metabolism, 2011 (14), 184 - 195
21803289
Published

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