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Strain
C57BL/6-Ephx2tm1.1Dcz Speer6-ps1Tg(Alb-cre)21Mgn

Summary Data Summary
Official Name C57BL/6-Ephx2tm1.1Dcz Speer6-ps1Tg(Alb-cre)21Mgn
Common Name sEH flox, Alb-cre, AlbCre,
Description Exons 11 and 12 of the Ephx2 gene were floxed and an FRT
flanked selection cassette was inserted via homologous
recombination. Flp mediated recombination removed the neo
cassette.

AlbCre: The transgene contains a 2.34 kb mouse albumin
enhancer/promoter (M. Magnuson verified mouse promoter,
personal communication), a nuclear localization
sequence-modified Cre recombinase gene and a 2.1 kb fragment
from the human growth hormone gene. The promoter is active
in hepatocyte cells of the liver. 7 copies of the transgene
are estimated to be present. Line 21 inserted into the gene
at 3172116-3172120 (Build GRCm38/mm10) resulting in a 4 bp
deletion. Founder line x has a copy number of approximately
10.
Development Status Phenotyping ongoing
Creation Method knockin
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 2


Investigators
NameInstitution
Aline MelloUniversity of California - Davis


Genomic Information
GeneAllele 1Allele 2Protocol
Ephx2knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedAlbCRENot Specified


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