University of California Davis
University of Cincinnati Medical Center
University of Massachusetts Medical School
University of Michigan Medical School
Vanderbilt University School of Medicine
Protocols & Methods
Reagents & Resources
Tissues & Samples
Conditions of Use
Energy Expenditure Analysis
Guidelines & Policies
University of Massachusetts Medical School
Tests for insulin resistance, glucose metabolism, insulin secretion, energy
balance, obesity, and serum/tissue factors of diabetes.
Director / Email
Jason Kim, Ph.D. -
Center: University of Massachusetts Medical School; Director: Jason Kim, Ph.D.
The Metabolism Core performs elegant and non-invasive metabolic experiments to assess insulin sensitivity, glucose/lipid/protein metabolism, body composition and energy balance in conscious mice.
The Analytical Core utilizes clinical chemistry analyzer and Luminex to perform high-throughput measurement of serum/tissue hormones, metabolites and cytokines known to affect metabolism
Animal Care Core
The Animal Care Core provides services and facilities for stable, biocontainment housing, husbandry, and health care of mice. The Core manages transfer of mice from the user's institution and testing of mice for the quarantine process.
The Islet Core provides comprehensive in vivo, ex vivo, and in vitro analysis of pancreatic function and islet structure. The Core services enhance whole body metabolic characterization given the interrelatedness of insulin action and insulin secretion, while altered islet function and mass play an important role in the onset of diabetes phenotypes (hyperglycemia).
The Cardiovascular Core provides state-of-the-art phenotyping of cardiovascular system in mouse models of metabolic disease and an easily accessible cardiovascular disease model pipeline. The Core services enhance whole body metabolic characterization given that cardiovascular complications represent the major source of morbidity and mortality in obesity and diabetes.
The Humanized Mouse Cell Transplantation and Assessment Core provides “humanized” mice that enable clinically relevant in vivo studies of human cells, tissues, and immune system without putting patients at risk. Humanized mice are immunodeficient mice engrafted with functional human cells and tissues and importantly address the scientific gap between human and mouse biology
The human gut microbiome consists of trillions of bacteria that have been shown to affect multiple organ systems including the brain, immune system, endocrine system, and metabolism, and may play an important role in the pathogenesis of major human diseases including type 2 diabetes. Our new Microbiome Core is directed by Dr. Beth McCormick (Professor and Vice Chair of Microbiology and Physiological Systems), who is a leading scientist in microbiome research, and provides expert knowledge and state-of-the-art tools for researchers to study gut microbiota in mouse models of human diseases to advance our understanding of this critical interplay. The Microbiome Core offers: • Consultation service for the design and implementation of gut microbiome studies • Sample preparation and quality control tests • Metagenomic 16S rRNA NextGen sequencing methodologies • Post-sequencing consultation for data analysis, interpretation, upload, and presentation • Fecal Microbiota Transplant (FMT) procedure to selectively alter gut microbiota in mice • Chronic and acute antibiotic treatment to induce altered gut microbiota in mice
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the MMPC using the following text:
Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.
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