@NationalMMPC

| Create Account | login

login

View Center

University of Massachusetts Medical School (Alumni MMPC)
http://umassmed.edu/umpc/index.aspx

Description	Tests for insulin resistance, glucose metabolism, insulin secretion, energy balance, obesity, and serum/tissue factors of diabetes.
Director / Email	Jason Kim, Ph.D. - jason.kim@umassmed.edu
General Contact	randall.friedline@umassmed.edu
Grant Number	DK093000
RRID	SCR_015366 (Cite This)

Center Cores:

	Center Core	Core Description	RRID
	Center: University of Massachusetts Medical School; Director: Jason Kim, Ph.D.
	Metabolism Core	performs elegant, physiological, and non-invasive metabolic experiments to assess insulin sensitivity hyperinsulinemic-euglycemic clamp & GTT/ITT), glucose/lipid/protein metabolism using labeled metabolites, body composition using 1H-MRS, energy balance (food/water intake, energy expenditure, physical activity) at varying temperature and light/dark cycle using TSE Metabolic Cage System with Environmental Chamber, and exercise capacity using treadmill in mice. The Core also conducts comprehensive drug trial studies for PK/PD, efficacy, and toxicity analysis with academic and pharmaceutical institutions.	SCR_015369
	Analytical Core	The Analytical Core utilizes Luminex, Cobas Clinical Chemistry Analyzer, and molecular experiments to perform a high-throughput, multiplexed analysis of serum/tissue/urine levels of hormones, cytokines, chemokines, electrolytes, and metabolites, liver/kidney/thyroid function panels, and metabolic/inflammatory signaling pathways. Samples can be directly sent to the Core or obtained from mice by the Core.	SCR_015365
	Animal Care Core	The Animal Core is the gateway to all Phenotyping Cores involving mice for phenotyping services, and the principal functions are: 1) Provision of high quality animal housing, husbandry, and health care by veterinarians and staff, 2) Processing of animal acquisition, quarantine, and health testing in preparation for phenotyping studies, 3) Coordination of standard quarantine screening (5 weeks) and accelerated quarantine screening (3 weeks) involving microbiological testing, 4) Transfer of mice between different Phenotyping Cores, and 5) Provision of special diet and animal procedures.	SCR_015368
	Islet Core	The Islet Core conducts sophisticated in vivo, ex vivo, and in vitro analysis of insulin secretion, islet function/structure, and pancreatic function using hyperglycemic clamp, perifusion, and molecular experiments in mice. The Core also performs histological and morphological analysis with islet isolation.	SCR_015370
	Cardiovascular Core	applies state-of-the-art high-frequency and high-resolution digital imaging platform with color Doppler mode (VisualSonics Vevo2100) to perform 2-D and M-mode echocardiography to non-invasively assess cardiac function and structure in mice. The Core also measures ECG/blood pressure and vascular/endothelial function, and conducts elegant micro-surgery procedures to generate mouse models of cardiovascular and peripheral vascular diseases.	SCR_015375
	Humanized Mouse	The Humanized Mouse Cell Transplantation and Assessment Core provides “humanized” mice that enable clinically relevant in vivo studies of human cells, tissues, and immune system without putting patients at risk. Humanized mice are immunodeficient mice engrafted with functional human cells and tissues and importantly address the scientific gap between human and mouse biology. The Core also provides expert in vivo functional analysis of transplanted human islets and stem cell-derived b-cells in immunodeficient mice that are highly valuable to the mouse research community.	SCR_015372
	Microbiome Core	Microbiome Core provides expert knowledge and metagenomics 16S rRNA NextGen sequencing tools for state-of-the-art analysis of gut microbiota to investigate their role in altered energy balance and metabolism in mice. The Core also offers Fecal Microbiota Transplant (FMT) and antibiotic treatment procedures to facilitate alterations in gut microbiota population.

Back to Top

MMPC web resource – Terms of Use

Warranty disclaimer and copyright notice

THE NATIONAL MMPC MAKES NO REPRESENTATION ABOUT THE SUITABILITY OR ACCURACY OF THE SOFTWARE OR DATA FOR ANY PURPOSE, AND MAKES NO WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR THAT THE USE OF THE SOFTWARE OR DATA WILL NOT INFRINGE ANY THIRD PARTY PATENTS, COPYRIGHTS, TRADEMARKS, OR OTHER RIGHTS. THE SOFTWARE AND DATA ARE PROVIDED "AS IS".

The Mouse Metabolic Phenotyping Centers (MMPC) is an NIDDK funded consortium and adheres to the NIH Data Sharing Policy.

MMPC clients make their data freely available whereby MMPC users may freely build upon, enhance and reuse those data for any purpose without restriction. Scholarly citation norms must be followed for content reuse. Please acknowledge the MMPC using the following text: 'The MMPC data used in this manuscript was supported by the NIDDK National Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997, www.mmpc.org)'. To cite specific MMPC centers, please use the appropriate RRID available from the MMPC website (https://www.mmpc.org/shared/centers.aspx).

Please note that the acknowledgment text includes a Research Resource Identifier (RRID) for the MMPC CU and Centers. Reproducibility is one of the corner stones of effective, open and transparent biomedical published research. However, too often, resources (e.g. model organisms, antibodies, and tools) are not reported with adequate detail to ensure others can replicate or expand upon the published results. The Research Resource Identification Initiative (#RII) seeks to change these limitations in reporting by the use of unique Research Resource Identifiers (RRIDs). This initiative is designed to encourage authors to provide identification of the types of resources used in their research by adding a globally unique accession number to the resources described in the their manuscripts. These identifiers, called RRIDs, will allow authors to cite the resources that they use in their manuscripts. RRIDs allow for easy tracking of all papers that have used the same resource making it easy to access how the same resources works in other scenarios.

It is expected that MMPC users follow scholarly citation norms, giving credit to fellow scholars when accessing/using protocols and data, including data derived by MMPC (such as summary data) and any plots, tables or screenshots depicting those data.

It is possible for invalid or incomplete results to be presented on the MMPC web site due to software bugs, data problems, or artifacts of human error. Data sets are not necessarily static; we reserve the right to post corrections and updates as needed.

Prohibited use. Data contributors and data users may not use MMPC in any unlawful manner, or in any manner that could impair MMPC services, security or functionality. Automated usage (webcrawlers and similar) must observe each page's "meta robots" html tags and space requests by ≥ 2 seconds. We reserve the right to block any IP associated with what we consider to be excessive or abusive usage patterns, and/or to take any action we deem necessary.

The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Menu

Home

Contact

About MMPC

Animal Husbandry

Tests Data

Search Data

Analysis

Clients

MMPC Centers

Newsletter

Interested in receiving MMPC News?

Mouse Phenotyping
@NationalMMPC

2017 National MMPC. All Rights Reserved.