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Vanderbilt University School of Medicine
https://vmmpc.org/

Description Tests for insulin resistance and glucose metabolism, heart and kidney function
as well as energy balance and feeding studies.
Director / Email Julio Ayala, Ph.D. - julio.e.ayala@vanderbilt.edu
General Contact mmpc@vanderbilt.edu
Grant Number DK135073
RRID SCR_015374 (Cite This)

Center Cores:

 Center CoreCore DescriptionRRIDInactive?

Center: Vanderbilt University School of Medicine; Director: Julio Ayala, Ph.D.

 Analytical Resources CoreThe Analytical Resources Core performs these major tests: plasma hormones, amino acids, lipids and lipoproteins, pathology and immunohistochemistry.SCR_015379Active
 Body Weight Regulation CoreThe Body Weight Regulation Core conducts these major tests: mouse models of bariatric surgery, indirect calorimetry, exercise, mitochondrial function, body composition, food consumption, telemetry, body temperature.SCR_015364Active
 Cardiovascular PathophysiologyThe Cardiovascular Pathophysiology and Complications Core conducts these major tests: morphology and histology, echocardiography, electrocardiography, blood pressure, vascular morphology, renal function, metabolic panel in state-of-the-art facilities.SCR_015353Active
 Education Training CoreThe Research Education Core (REC), led by Dr. Roumie, will ensure a comprehensive education and robust career development for LHS scholars, including both academic and operational leaders. REC Focus Areas Protecting each scholar's time to learn LHS fundamentals and develop the specific competencies necessary to build a program that will improve the healthcare system in which they are embedded. Sustaining and broadening a tradition of excellence in interdisciplinary research and training. Providing strong interdisciplinary mentor teams in the context of career development in LHS. Anchoring the education program in structured didactic learning, with complementary experiential learning through the conduct of research. Engaging mentors as facilitators with active roles in advising, pacing, problem-solving, and gaining buy-in from operational leaders for embedded research programs and projects. Maximizing RAPID-LHS scholars’ access to Research and Data Analysis Core (RDAC) resources and continuously monitoring progress to enhance each scholar's career outcomes and scientific products. Encouraging scientific questions that allow for interventions that resonate with patient need so that all people can reach their full health potential. Active
 Islet Phenotyping CoreThe Islet and Pancreas Analysis (IPA) Core assists VDRC’s large group of renowned and collaborative investigators who are studying a broad spectrum of islet-related processes, ranging from the function of islet-enriched factors and intracellular signaling to in vivo physiology and maintenance of hormone secretory profiles. VDRC investigators, with the assistance of the IPA Core, are performing sophisticated functional, genetic, and molecular-level comparisons to various physiological stresses in islets (aging, predisposing genetic abnormalities, etc.) that underlie or profoundly influence both type 1 and type 2 diabetes. Active
 Metabolic Regulation CoreThe Metabolic Regulation Core conducts these major tests: vein/artery cannulations, glucose and insulin clamps in conscious unstressed mice, glucose tolerance test, tissue specific glucose/fatty acid uptake, gluconeogenesis/glycogenolysis, metabolic flux analysis, optical imaging of gene expression/cellular events, isolation of pancreatic islets /insulin secretion.SCR_015377Active

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