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Experiment

Analytical Study on Hormones & Metabolites in Adipose-Specific Rictor KO Mice
Summary Data Summary
Investigator Guertin, David
Description Normal adipose tissue growth and function is critical to maintaining metabolic
homeostasis and its excess (e.g. obesity) or absence (e.g. lipodystrophy) is
associated with severe metabolic disease. The goal of this study was to
understand the mechanisms maintaining healthy adipose tissue growth and
function.

Adipose tissue senses and responds to systemic changes in growth factor and
nutrient availability; in cells mTORC1 regulates metabolism in response to
growth factors and nutrients. Thus, mTORC1 is poised to be a critical
intracellular regulator of adipocyte metabolism. Here, we investigate the role
of mTORC1 in mature adipocytes by generating and characterizing mice in which
the Adiponectin-Cre driver is used to delete floxed alleles of Raptor, which
encodes an essential regulatory subunit of mTORC1.
Status Completed
Public Release 3/22/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagExperiment / ControlExperiment DescriptionNomenclature
Data Analysis
TypeCount
Animals17
Experimental Conditions1
Catalog Items4
Curation Info (# flags)3
Phenotype Assays4
Phenotype Measurements68
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J +/+
0
9
0
adipose-specific raptor knockout
0
8
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Experimental Group



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