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Experiment

Serum Lipoploysaccharide Binding Protein (LBP) levels in letrozole-treated
female mice (cohort2)
Summary Data Summary
Investigator Thackray, Varykina
Description Letrozole treatment of pubertal female mice results in hallmarks of PCOS
including elevated androgens, anovulation, polycystic ovaries and a metabolic
phenotype. Puberal (4 week old) female mice were implanted with a placebo or
letrozole pellet (50 ug/day) and treated for 5 weeks. Mice were had ad libitum
access to food and water. Mice were sacrificed with isoflurance and blood was
collected via the vena cava and spun down to collect serum.

Applicable research area(s): Metabolism
Status Completed
Public Release 5/15/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals12
Experimental Conditions4
Catalog Items1
Curation Info (# flags)1
Phenotype Assays1
Phenotype Measurements12
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6N
12
0
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Letrozole
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery. These are continuous release pellets.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 µg/day
micrograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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