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Experiment

Circulating corticosterone levels in liver specific Klf15 KO mice Part 3
Summary Data Summary
Investigator Haldar, Saptarsi
Description KLF15 influence corticosterone level.

Classic physiological studies have documented the endurance-promoting effects of
glucocorticoid (GC) hormones on skeletal muscle. Pharmacologic GC therapy also
improves muscle function in patients with Duchenne muscular dystrophy (DMD), a
genetic muscle-wasting disease. Despite these well-established physiological and
clinical observations, the molecular basis underlying the beneficial effects of
GCs in skeletal muscle remains obscure. This study shows that physiological
effects of GCs on muscle endurance and their therapeutic effect in DMD are
mediated, in part, via activation of a potent metabolic gene called Kruppel-like
factor 15 (KLF15). Importantly, KLF15 does not drive GC-mediated muscle wasting.
These data shed light on the poorly understood ergogenic properties of GCs,
findings that may inform steroid-sparing therapies for DMD and other muscle
diseases.

Applicable research area(s): Metabolism
Status Completed
Public Release 8/4/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainMetadataAnimal CountExperiment Description
Data Analysis
TypeCount
Animals28
Experimental Conditions5
Catalog Items1
Curation Info (# flags)4
Phenotype Assays1
Phenotype Measurements56
Histology Images0
Publications0
Phenotypes2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J +/+
0
13
0
Klf15 Liver KO
0
15
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.
 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 LabDiet 5001
crude protein (23.0%), crude fat (4.5%), crude fiber (6.0%), Ash (< 8.0%), minerals (2.5%)

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)


Phenotype Assays Add / Edit



No documents found.

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