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Experiment

Serum Lipoploysaccharide Binding Protein (LBP) levels in letrozole-treated
female mice (cohort4)
Summary Data Summary
Investigator Thackray, Varykina
Description Puberal (4 week old) female mice were implanted with a placebo or letrozole
pellet (50 ug/day) and treated for 5 weeks. Mice were given adlib access to food
and water. Mice were fasted for 5 hours and then terminated using isoflurane and
blood was collected and spun down to collect serum for analysis.

Letrozole treatment of pubertal female mice results in hallmarks of PCOS
including elevated androgens, anovulation, polycystic ovaries and a metabolic
phenotype.

Applicable research area(s): Metabolism
Status Completed
Public Release 12/5/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals20
Experimental Conditions4
Catalog Items2
Curation Info (# flags)2
Phenotype Assays1
Phenotype Measurements20
Histology Images0
Publications0
Documents1


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6N
20
0
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Letrozole
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery. These are continuous release pellets.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 µg/day
micrograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



No documents found.

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