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Experiment

Effect of maternal antibodies on neonatal body composition
Summary Data Summary
Investigator Barton, Greg
Description Antibody negative (B6.Cg-Ighmtm1Cgn) and positive (B6.Cg-Ighmtm1Cgn/+) females
were crossed with C57BL6/J males. Individual genotype from the cross of female
B6.129S2-Ighmtm1Cgn/+ and C57BL6/J males are unknown and strain defined as
B6;B6.129S2-Ighmtm1Cgn . However, mice contain at least one functional copy of
the Imgh gene and are either B6.129S2-Ighmtm1Cgn/+ or wild type.Pups from cross
were not genotyped so genotype of offspring from first cross are all het for KO
and named B6.129S2-Ighmtm1Cgn/+. Body composition of resulting pup were assessed
using DEXA at 26 days of age.

It has been found that compared to control offspring, pups lacking maternal
antibodies exhibit a 'growth faltering' phenotype around d18-d28 of age. The PI
is interested in characterizing the mechanisms that lead to this lag in weight
gain during this period. As a first step, the PI would like to characterize the
physiological differences between these maternal antibody sufficient and
deficient pups. For example, do mice lacking maternal antibodies exhibit
differences in adipose tissue deposition, muscle growth and bone growth? Or is
it just a subset of these tissues that is affected? Based on some preliminary
data, it is hypothesize that adipose tissue deposition is altered in pups
lacking maternal antibodies, whereas muscle (& bone) formation is normal.

Applicable research area(s): Metabolism
Status Completed
Public Release 4/12/2020
Animal Age Measured In: day(s) post-natal (d)
Data Analysis
TypeCount
Animals20
Experimental Conditions1
Catalog Items1
Curation Info (# flags)0
Phenotype Assays10
Phenotype Measurements200
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
muMT-/+
6
2
0
B6;B6.129S2-Ighmtm1Cgn
2
10
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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