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Experiment

Effect of Tmem55b ASOs on body composition
Summary Data Summary
Investigator Kim, Mee Jean
Description 6 Wk old male C57BL/6N Hsd mice were put on Western Diet for 3 weeks and treated
with one of two Tmem55b anti-sense oligonucleotides (ASOs) or a control ASO at a
dose of 25mg/kg/wk. ASOs were administered weekly by i.p injection for 12-14
weeks. DEXA was performed (after 1 week acclimation (no dosing)) to investigate
whether there were body composition differences between the control ASO
(missense/nonspecific) and the Tmem55b ASOs.

Applicable research area(s): Diabetes, Metabolism, Cardiovascular
Status Completed
Public Release 4/8/2017
Animal Age Measured In: day(s) post-natal (d)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals9
Experimental Conditions3
Catalog Items3
Curation Info (# flags)1
Phenotype Assays9
Phenotype Measurements81
Histology Images0
Publications0
Documents2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6NHSD
0
9
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Administered

 ASO
Control anti-sense oligonucleotide
 ASO-1
Target anti-sense oligonucleotide (ASO)-1
 ASO-2
Target anti-sense oligonucleotide (ASO)-2

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Teklad - 88137
Harlan Teklad TD.88137 (Western Diet)



No documents found.

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