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Experiment

Circulating levels of hormones and proinflammatory markers in HopX Tg mice
Summary Data Summary
Investigator Patel, Vickas
Description We used HopX transgenic mice that develop cardiac hypertrophy and inducible
atrial fibrillaion on a regualr chow diet with ad lib access to water for the
entire duration they mice were housed. Blood was obtained by cardiac puncture
after euthanasia with pentobarbital overdoase but no heparin was given to the
mice. The blood was placed in EDTA coated tubes and the plasma obtianed after
centrifugation.

HopX transgenic mice with cardiomyocyte-specific over-expression develop cardiac
hypertrophy and inducible atrial arrhythmias that mirror the clinical state with
heart disease and atrial arrhythmias.
Status Completed
Public Release 5/19/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals12
Experimental Conditions8
Catalog Items4
Curation Info (# flags)1
Phenotype Assays10
Phenotype Measurements120
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
HopX(Tg)
5
7
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Administered

 CI994
Tacedinaline - a histone deacetylase (HDAC) inhibitor
 SAHA
Suberoylanilide hydroxamic acid - a histone deacetylase (HDAC) inhibitor
 Vehicle
Vehicle - Control

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 LabDiet 5053
PicoLab Rodent Diet 20, 21.0% protein (Calories: 24.5% protein, 13.1% Fat, 62.4% Carbohydrate)

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)



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