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Publication
Correlation of Retinal Structure and Visual Function Assessments in Mouse
Diabetes Models.
Authors Sheskey SR, Antonetti DA, Rentería RC, Lin CM
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Investigative ophthalmology & visual science
Year 2021
Date Published 8/1/2021
Volume : Pages 62 : 20
PubMed Reference 34410299
Abstract Diabetic retinopathy results in vision loss with changes to both retinal blood
vessels and neural retina. Recent studies have revealed that animal models of
diabetes demonstrate early loss of visual function. We explored the time course
of retinal change in three different mouse models of diabetes in a longitudinal
study using in vivo measures of retinal structure (optical coherence tomography
[OCT]) and visual function (optomotor and pupillary responses)., OCT analysis of
retinal microstructure, optokinetic response as a measure of visual acuity, and
pupillary response to light stimulation were compared among the db/db,
Ins2Akita, and streptozotocin (STZ)-induced mouse models of diabetes at 1.5, 3,
6, and 9 months of diabetes., The db/db, Ins2Akita, and STZ-induced models of
diabetes all exhibited vision loss and retinal thinning as disease progressed.
Both structural changes and functional measures were significantly correlated
with the blood glucose levels. Despite this, vision loss and retinal thinning
were not consistently correlated, except for the inner retinal layer thickness
at 6 months of diabetes., This longitudinal study compiled structural measures
and functional outcome data for type 1 and 2 diabetes mouse models commonly used
for diabetes studies and demonstrated an overall decline in retinal-related
health in conjunction with weight change and blood glucose alterations. The
relationship between the structural change and functional outcome could be
correlative but is not necessarily causative, as retinal thinning was not
sufficient to explain visual acuity decline.




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