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Publication
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve
gastrectomy in mice.
Authors Bozadjieva-Kramer N, Shin JH, Shao Y, Gutierrez-Aguilar R, Li Z, Heppner KM,
Chiang S, Vargo SG, Granger K, Sandoval DA, MacDougald OA, Seeley RJ
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Nature communications
Year 2021
Date Published 8/1/2021
Volume : Pages 12 : 4768
PubMed Reference 34362888
Abstract Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive
but provide the most effective improvements in obesity and Type 2 diabetes. We
hypothesized a potential role for the gut hormone Fibroblast-Growth Factor 15/19
which is increased after VSG and pharmacologically can improve energy
homeostasis and glucose handling. We generated intestinal-specific FGF15
knockout (FGF15INT-KO) mice which were maintained on high-fat diet. FGF15INT-KO
mice lost more weight after VSG as a result of increased lean tissue loss.
FGF15INT-KO mice also lost more bone density and bone marrow adipose tissue
after VSG. The effect of VSG to improve glucose tolerance was also absent in
FGF15INT-KO. VSG resulted in increased plasma bile acid levels but were
considerably higher in VSG-FGF15INT-KO mice. These data point to an important
role after VSG for intestinal FGF15 to protect the organism from deleterious
effects of VSG potentially by limiting the increase in circulating bile acids.




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