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Publication
Bile Acids, Their Receptors, and the Gut Microbiota.
Authors Poland JC, Flynn CR
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Physiology (Bethesda, Md.)
Year 2021
Date Published 7/1/2021
Volume : Pages 36 : 235 - 245
PubMed Reference 34159805
Abstract Bile acids (BAs) are a family of hydroxylated steroids secreted by the liver
that aid in the breakdown and absorption of dietary fats. BAs also function as
nutrient and inflammatory signaling molecules, acting through cognate receptors,
to coordinate host metabolism. Commensal bacteria in the gastrointestinal tract
are functional modifiers of the BA pool, affecting composition and abundance.
Deconjugation of host BAs creates a molecular network that inextricably links
gut microtia with their host. In this review we highlight the roles of BAs in
mediating this mutualistic relationship with a focus on those events that impact
host physiology and metabolism.




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