mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on
Triglyceride Metabolism via Androgen Receptor in Male Mice.
Authors Palmisano BT, Zhu L, Litts B, Burman A, Yu S, Neuman JC, Anozie U, Luu TN,
Edington EM, Stafford JM
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Metabolites
Year 2021
Date Published 5/1/2021
Volume : Pages 11 : Not Specified
PubMed Reference 34065318
Abstract Mechanisms of sex differences in hypertriglyceridemia remain poorly understood.
Small heterodimer partner (SHP) is a nuclear receptor that regulates bile acid,
glucose, and lipid metabolism. SHP also regulates transcriptional activity of
sex hormone receptors and may mediate sex differences in triglyceride (TG)
metabolism. Here, we test the hypothesis that hepatic SHP mediates sex
differences in TG metabolism using hepatocyte-specific SHP knockout mice. Plasma
TGs in wild-type males were higher than in wild-type females and hepatic
deletion of SHP lowered plasma TGs in males but not in females, suggesting
hepatic SHP mediates plasma TG metabolism in a sex-specific manner.
Additionally, hepatic deletion of SHP failed to lower plasma TGs in
gonadectomized male mice or in males with knockdown of the liver androgen
receptor, suggesting hepatic SHP modifies plasma TG via an androgen receptor
pathway. Furthermore, the TG lowering effect of hepatic deletion of SHP was
caused by increased clearance of postprandial TG and accompanied with decreased
plasma levels of ApoC1, an inhibitor of lipoprotein lipase activity. These data
support a role for hepatic SHP in mediating sex-specific effects on plasma TG
metabolism through androgen receptor signaling. Understanding how hepatic SHP
regulates TG clearance may lead to novel approaches to lower plasma TGs and
mitigate cardiovascular disease risk.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.