mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Transcriptional control of parallel-acting pathways that remove specific
presynaptic proteins in remodeling neurons.
Authors Miller-Fleming TW, Cuentas-Condori A, Manning L, Palumbos S, Richmond JE, Miller
DM
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal The Journal of neuroscience : the official journal of the Society for Neuroscience
Year 2021
Date Published 5/1/2021
Volume : Pages Not Specified : Not Specified
PubMed Reference 34045310
Abstract Synapses are actively dismantled to mediate circuit refinement, but the
developmental pathways that regulate synaptic disassembly are largely unknown.
We have previously shown that the epithelial sodium channel ENaC/UNC-8 triggers
an activity-dependent mechanism that drives the removal of presynaptic proteins
liprin-a/SYD-2, Synaptobrevin/SNB-1, RAB-3 and Endophilin/UNC-57 in remodeling
GABAergic neurons in C. elegans (Miller-Fleming et al., 2016). Here, we report
that the conserved transcription factor Iroquois/IRX-1 regulates UNC-8
expression as well as an additional pathway, independent of UNC-8, that
functions in parallel to dismantle functional presynaptic terminals. We show
that the additional IRX-1-regulated pathway is selectively required for the
removal of the presynaptic proteins, Munc13/UNC-13 and ELKS, which normally
mediate synaptic vesicle fusion and neurotransmitter release. Our findings are
notable because they highlight the key role of transcriptional regulation in
synapse elimination during development and reveal parallel-acting pathways that
coordinate synaptic disassembly by removing specific active zone
proteins.SIGNIFICANT STATEMENT:Synaptic pruning is a conserved feature of
developing neural circuits but the mechanisms that dismantle the presynaptic
apparatus are largely unknown. We have determined that synaptic disassembly is
orchestrated by parallel-acting mechanisms that target distinct components of
the active zone. Thus, our finding suggests that synaptic disassembly is not
accomplished by en masse destruction but depends on mechanisms that dismantle
the structure in an organized process.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.