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Publication
Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a
translational study.
Authors Chavanelle V, Otero YF, Le Joubioux F, Ripoche D, Bargetto M, Vluggens A,
Montaurier C, Pickering G, Ducheix G, Dubray C, Dualé C, Boulliau S, Macian N,
Marceau G, Sapin V, Dutheil F, Guigas B, Maugard T, Boisseau N, Cazaubiel M,
Peltier SL, Sirvent P
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal American journal of physiology. Endocrinology and metabolism
Year 2021
Date Published 6/1/2021
Volume : Pages 320 : E1119 - E1137
PubMed Reference 33938234
Abstract Global prevalence of type 2 diabetes (T2D) is rising and may affect 700 million
people by 2045. Totum-63 is a polyphenol-rich natural composition developed to
reduce the risk of T2D. We first investigated the effects of Totum-63
supplementation in high-fat diet (HFD)-fed mice for up to 16?wk and thereafter
assessed its safety and efficacy (2.5?g or 5?g per day) in 14 overweight men
[mean age 51.5?yr, body mass index (BMI) 27.6?kg·m-2] for 4?wk. In HFD-fed mice,
Totum-63 reduced body weight and fat mass gain, whereas lean mass was unchanged.
Moreover, fecal energy excretion was higher in Totum-63-supplemented mice,
suggesting a reduction of calorie absorption in the digestive tract. In the gut,
metagenomic analyses of fecal microbiota revealed a partial restoration of
HFD-induced microbial imbalance, as shown by principal coordinate analysis of
microbiota composition. HFD-induced increase in HOMA-IR score was delayed in
supplemented mice, and insulin response to an oral glucose tolerance test was
significantly reduced, suggesting that Totum-63 may prevent HFD-related
impairments in glucose homeostasis. Interestingly, these improvements could be
linked to restored insulin signaling in subcutaneous adipose tissue and soleus
muscle. In the liver, HFD-induced steatosis was reduced by 40% (as shown by
triglyceride content). In the subsequent study in men, Totum-63 (5?g·day-1)
improved glucose and insulin responses to a high-carbohydrate breakfast test
(84% kcal carbohydrates). It was well tolerated, with no clinically significant
adverse events reported. Collectively, these data suggest that Totum-63 could
improve glucose homeostasis in both HFD-fed mice and overweight individuals,
presumably through a multitargeted action on different metabolic organs.NEW &
NOTEWORTHY Totum-63 is a novel polyphenol-rich natural composition developed to
reduce the risk of T2D. Totum-63 showed beneficial effects on glucose
homeostasis in HFD-fed mice, presumably through a multitargeted action on
different metabolic organs. Totum-63 was well tolerated in humans and improved
postprandial glucose and insulin responses to a high-carbohydrate breakfast
test.




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