mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Sexually divergent cortical control of affective-autonomic integration.
Authors Wallace T, Schaeuble D, Pace SA, Schackmuth MK, Hentges ST, Chicco AJ, Myers B
Submitted By Submitted Externally on 12/3/2021
Status Published
Journal Psychoneuroendocrinology
Year 2021
Date Published 7/1/2021
Volume : Pages 129 : 105238
PubMed Reference 33930756
Abstract Depression and cardiovascular disease reduce quality of life and increase
mortality risk. These conditions commonly co-occur with sex-based differences in
incidence and severity. However, the biological mechanisms linking the disorders
are poorly understood. In the current study, we hypothesized that the
infralimbic (IL) prefrontal cortex integrates mood-related behaviors with the
cardiovascular burden of chronic stress. In a rodent model, we utilized
optogenetics during behavior and in vivo physiological monitoring to examine how
the IL regulates affect, social motivation, neuroendocrine-autonomic stress
reactivity, and the cardiac consequences of chronic stress. Our results indicate
that IL glutamate neurons increase socio-motivational behaviors specifically in
males. IL activation also reduced endocrine and cardiovascular stress responses
in males, while increasing reactivity in females. Moreover, prior IL stimulation
protected males from subsequent chronic stress-induced sympatho-vagal imbalance
and cardiac hypertrophy. Our findings suggest that cortical regulation of
behavior, physiological stress responses, and cardiovascular outcomes
fundamentally differ between sexes.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.